PRECISEU (PeRsonalised medicine Empowerment Connecting Innovation ecoSystems across EUrope) is a Horizon Europe Regional Innovation Valleys (RIVs) action that connects regional innovation ecosystems to accelerate the adoption of personalised medicine and related deep-tech health solutions in Europe.

PRECISEU aims to accelerate the integration of Personalised Medicine (PM) across Europe by strengthening regional innovation ecosystems and bridging the gap between regions.

This initiative aligns with the European Union's deep-tech innovation goals, particularly in healthcare, supporting the development of advanced therapies and the secondary use of health data.

Over the next five years, PRECISEU will contribute to making Europe a leader in PM, enhancing patient access to cutting-edge healthcare solutions and supporting the EU’s sustainable transition and wellbeing agenda.

Despite rapid scientific progress in personalised medicine, its implementation across Europe remains fragmented and uneven. Significant disparities exist between regions in terms of innovation capacity, access to advanced therapies, digital health infrastructure, and the ability to translate research results into clinical practice.

Many regions lack the necessary cross-sector collaboration between research institutions, healthcare providers, industry, policymakers, and patient organisations. This fragmentation slows down the uptake of Advanced Therapy Medicinal Products (ATMPs), limits the effective use of health data, and creates barriers to scaling deep-tech healthcare innovations beyond local ecosystems.

Additionally, differences in regulatory frameworks, investment capacity, and technology readiness levels contribute to widening innovation gaps between more advanced and less developed regions. As a result, patients across Europe do not benefit equally from cutting-edge personalised healthcare solutions.

Addressing these systemic challenges requires stronger interregional cooperation, improved knowledge transfer mechanisms, and coordinated innovation ecosystems capable of accelerating the adoption of personalised medicine at scale.

Objectives

PRECISEU aims to accelerate the adoption and scaling of personalised medicine across Europe by strengthening interregional innovation ecosystems and reducing disparities in innovation capacity.

The project pursues the following key objectives:

• To enhance collaboration between regional innovation actors, including research institutions, healthcare providers, industry, clusters, public authorities, and patient organisations.

• To support the development and scaling of innovations in Advanced Therapy Medicinal Products (ATMPs) and health data–driven solutions.

• To reduce fragmentation between regions with different levels of innovation maturity.

• To facilitate knowledge transfer, best-practice exchange, and coordinated policy alignment across European regions.

• To improve patient access to personalised healthcare solutions by accelerating translation from research to market and clinical implementation.

Approach

PRECISEU adopts a structured interregional collaboration model built on ecosystem integration, co-creation, and capacity building.

The project connects 12 European regional innovation ecosystems and enables them to jointly develop and implement innovation roadmaps in personalised medicine. Through Joint Interregional Projects (JIPs), matchmaking activities, open calls, training programmes, and best-practice exchanges, PRECISEU supports the scaling of deep-tech healthcare innovations across multiple regions.

The approach combines:

• Ecosystem mapping and gap analysis

• Policy coordination and strategic alignment

• Innovation support services for SMEs and research actors

• Cross-regional pilot actions and collaborative projects

• Stakeholder engagement, including patients and healthcare providers

By integrating technological innovation, policy support, and ecosystem strengthening, PRECISEU creates a framework for sustainable and scalable personalised medicine deployment across Europe.

Expected Results

PRECISEU delivers tangible outcomes aimed at strengthening Europe’s personalised medicine ecosystem and accelerating the deployment of advanced healthcare innovations. Key results include:

• Stronger interregional collaboration between 12 European innovation ecosystems.

• Implementation of Joint Interregional Projects (JIPs) supporting scalable personalised medicine solutions.

• Improved capacity of regions to develop and adopt Advanced Therapy Medicinal Products (ATMPs) and health data–driven innovations.

• Enhanced knowledge transfer mechanisms and structured best-practice exchange.

• Increased participation of SMEs and research organisations in cross-regional innovation activities.

• Greater alignment of regional innovation strategies and policies in personalised healthcare.

Added Value

PRECISEU generates significant European added value by addressing fragmentation and disparities in innovation capacity across regions. Instead of isolated local initiatives, the project enables coordinated scaling of innovations across multiple territories.

Its value lies in:

• Reducing the innovation gap between advanced and emerging regions.

• Accelerating the translation of research into market-ready and clinically applicable solutions.

• Improving patient access to personalised treatments across Europe.

• Strengthening Europe’s competitiveness in deep-tech healthcare and personalised medicine.

• Building sustainable, long-term interregional partnerships beyond the project duration.

By connecting innovation ecosystems, policy frameworks, and healthcare stakeholders, PRECISEU creates a scalable and sustainable model for the future of personalised medicine in Europe.